ESTETROL, CAS No. 15183-37-6

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15183-37-6

Catalog No. EBD3040239

CAS 15183-37-6

Name ESTETROL

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Basic Information

Synonyms: ESTETROL 15WEI-HYDROXYESTRIOL 15A-HYDROXYESTRIOL 15-ALPHA-HYDROXYESTRIOL ESTRA-1,3,5(10)-TRIENE-3,15A,16A,17-TETROL ESTRA-1,3,5(10)-TRIENE-3,15WEI,16WEI,17WEI-TETROL 3,15A,16A,17-TETRAHYDROXYESTRA-1,3,5(10)-TRIENE 3,15WEI,16WEI,17WEI-TETRAHYDROXYESTRA-1,3,5(10)-TRIENE (15A,16A,17)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-TETROL 1,3,5(10)-ESTRATRIEN-3,15-ALPHA,16-ALPHA,17-BETA-TETROL (15alpha,16alpha,17beta)-estra-1,3,5(10)-triene-3,15,16,17-tetrol

Molecular Formula: C18H24O4

Molecular Weight: 304.38

Categories: Medicinal Chemistry > APIs and Their Salts > Endocrine & Metabolic Drugs Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products

Product Description:

Estetrol (E4) is a natural estrogenic steroid hormone, specifically a 15α-hydroxylated metabolite of estriol. It is produced exclusively by the human fetal liver during pregnancy and is classified as a native estrogen with a unique structure and pharmacological profile. Its primary application is in pharmaceutical development as an active pharmaceutical ingredient (API) for hormone therapy. Estetrol exhibits selective tissue activity, acting as an agonist on estrogen receptors in certain tissues (e.g., bone, vagina) while displaying antagonistic or neutral effects in others (e.g., breast, endometrium). This profile underpins its clinical use in combined oral contraceptives and menopausal hormone therapy, offering efficacy with a potentially improved safety window regarding thromboembolic risk and breast tissue stimulation compared to classical estrogens. As a naturally occurring human hormone, it is also of significant interest in endocrinology research and as a reference standard in bioanalytical studies. Its synthesis is achieved through complex steroid chemistry, but its primary identity and value are defined by its specific endocrine activity and therapeutic applications.

Physical Properties

Boiling Point: 491.9 °C at 760 mmHg

Flash Point: 231.7 °C

Density: 1.343 g/cm3