5-Methyl hydrogen L-glutamate, CAS No. 1499-55-4

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

1499-55-4

Catalog No. EBD23185

CAS 1499-55-4

Name 5-Methyl hydrogen L-glutamate

Get Quote

Basic Information

Synonyms: 5-methyll-glutamate l-glutamicacid,g-methylester h-l-glu(me)-oh h-glu(ome)-oh gamma-l-glu-methylester gamma-methyl-l-glutamate L-Glutamicacid-5-methylester (2S)-2-amino-5-methoxy-5-oxopentanoicacid(non-preferredname) 2-amino-5-methoxy-5-oxopentanoicacid(non-preferredname) O-acetyl-L-homoserine 4-amino-5-methoxy-5-oxopentanoicacid(non-preferredname) L-GlutamicAcid5-MethylEster L-Glutamicacidgamma-methylester

Molecular Formula: C6H11NO4

Molecular Weight: 161.16

MDL Number: MFCD00002632

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

5-Methyl hydrogen L-glutamate is a derivative of the amino acid L-glutamic acid, where the ж├-carboxyl group is esterified to form a methyl ester. It retains the chiral center of the natural L-configuration and is commonly used as a protected building block in peptide synthesis. This compound serves primarily as a key intermediate in the preparation of glutamic acid-containing peptides and pharmaceutical intermediates. Its methyl ester group provides selective protection for the side-chain carboxyl, enabling regioselective modifications in drug discovery and medicinal chemistry. It is also utilized in biochemical research to study glutamate metabolism and transport mechanisms. As a versatile synthetic building block, it is frequently employed in organic synthesis for constructing complex molecules, particularly in the development of neuroactive compounds and enzyme inhibitors. Its stability and solubility in organic solvents make it suitable for standard coupling reactions in both academic and industrial settings.

Physical Properties

Melting Point: 182 °C (dec.)(lit.)

Boiling Point: 316.1 °C at 760 mmHg

Flash Point: 145 °C

Density: 1.242 g/cm3

Refractivity: 29 ° (C=2, 6mol/L HCl)

Storage: 2-8°C

Analytical Data

Appearance: white amorphous powder