6-Bromopyridine-3-carbaldehyde, CAS No. 149806-06-4

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149806-06-4

Catalog No. EBD322612

CAS 149806-06-4

Name 6-Bromopyridine-3-carbaldehyde

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Basic Information

Synonyms: 2-Bromo-5-formylpyridine 2-BROMOPYRIDINE-5-CARBALDEHYDE 2-BROMOPYRIDINE-5-CARBOXALDEHYDE 2-BROMO-5-PYRIDINECARBOXALDEHYDE 6-BROMO-PYRIDINE-3-CARBALDEHYDE 6-BROMO-3-PYRIDINECARBOXALDEHYDE 6-Bromopyridine-3-carbaldehyde

Molecular Formula: C6H4BrNO

Molecular Weight: 186.01

MDL Number: MFCD04115419

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

6-Bromopyridine-3-carbaldehyde is a heterocyclic building block featuring a pyridine ring substituted with a bromine atom at the 2-position and an aldehyde group at the 5-position. This compound serves as a versatile intermediate in organic synthesis, particularly for constructing complex molecules via cross-coupling reactions (e.g., Suzuki, Heck) due to the reactive bromine handle, while the aldehyde group enables further functionalization through condensation or reduction. Its primary application lies in pharmaceutical research and development, where it is used to synthesize drug candidates targeting neurological disorders, oncology, and infectious diseases. The pyridine core is a common motif in bioactive molecules, and the dual functionality allows for rapid diversification in medicinal chemistry. Additionally, it is employed as a synthetic building block in agrochemical and material science research. As a halogenated aldehyde, it requires standard handling precautions to avoid moisture and light exposure. Its high reactivity and commercial availability make it a staple in both academic and industrial laboratories for constructing heterocyclic libraries and lead optimization.

Physical Properties

Melting Point: 104-110 °C(lit.)

Boiling Point: 284.1 °C at 760 mmHg

Flash Point: 125.6 °C

Density: 1.683 g/cm3

Analytical Data

Appearance: light yellow cryst