[1,1'-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride, (αR,γS)-, CAS No. 149690-12-0

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

149690-12-0

Catalog No. EBD3326530

CAS 149690-12-0

Name [1,1'-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride, (αR,γS)-

Get Quote

Basic Information

Synonyms: [1,1'-Biphenyl]-4-pentanoicacid,γ-amino-α-methyl-,ethylester,hydrochloride,(αR,γS)- (2R,4S)-ethyl5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoatehydrochloride (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoicacidethylesterhydrochloride

Molecular Formula: C20H26ClNO2

Molecular Weight: 347.88

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs

Product Description:

(2R,4S)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride is a chiral amino acid ester derivative featuring a biphenyl moiety. It serves as a crucial chiral intermediate in the synthesis of Aliskiren, a direct renin inhibitor used for the treatment of hypertension (high blood pressure). The specific (2R,4S) stereochemistry is essential for the biological activity of the final drug. This compound is a key building block in the multi-step synthesis of Aliskiren, where it is incorporated to construct the core structure with the required absolute configuration. Its production and supply are primarily driven by the pharmaceutical industry's demand for high-purity intermediates for API manufacturing.

Physical Properties

Storage: −20°C