Methyl 4-chloro-4-oxobutanoate, CAS No. 1490-25-1

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1490-25-1

Catalog No. EBD30537

CAS 1490-25-1

Name Methyl 4-chloro-4-oxobutanoate

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Basic Information

Synonyms: 4-chloro-4-oxo-butanoicacimethylester succinicacidmonomethylesterchloride 3-(chloroformyl)methylpropionate 3-(carbomethoxy)propionylchloride 3-carbomethoxypropionylechloride methyl4-chloro-4-oxobutyrate 216-077-0 Methyl4-chloro-4-oxobutanoate Methylsuccinylchloride Methyl3-(chloroformyl)propionate

Molecular Formula: C5H7ClO3

Molecular Weight: 150.56

MDL Number: MFCD00000750

Categories: Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters Synthetic Chemistry > Basic Synthetic Reagents > Other Basic Synthetic Reagents

Product Description:

Succinic acid monomethyl ester chloride, also known as methyl hydrogen succinyl chloride or 4-methoxy-4-oxobutanoyl chloride, is a reactive organic compound. It is a colorless to pale yellow liquid with a pungent odor. Its molecular formula is C5H7ClO3, and it features a carboxylic acid chloride group and a methyl ester group on a succinic acid backbone, making it a bifunctional reagent. This compound is primarily used as a versatile acylating agent and a key synthetic building block in organic chemistry. Its main application lies in the synthesis of various amides, esters, and other derivatives. It serves as a crucial intermediate in the preparation of pharmaceuticals, agrochemicals, and functional materials. For instance, it is employed in the synthesis of certain drug candidates and active pharmaceutical ingredients (APIs) where the succinate moiety is required. Due to the presence of the highly reactive acid chloride group, it readily reacts with nucleophiles such as amines and alcohols. It is moisture-sensitive and hydrolyzes upon contact with water, releasing hydrogen chloride. Therefore, it must be handled under anhydrous conditions and with appropriate personal protective equipment, including gloves and eye protection, in a well-ventilated fume hood.

Physical Properties

Boiling Point: 58-65 °C/3 mmHg(lit.)

Flash Point: 74 °C

Density: 1.223 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.44(lit.)

Storage: 2-8°C

Safety Information

Packing Level: II

Hazard Category: 8

Transport Codes: 3265

Analytical Data

Appearance: clear liquid