(2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)-methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]-octan-3-amine, CAS No. 147116-67-4

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147116-67-4

Catalog No. EBD246578

CAS 147116-67-4

Name (2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)-methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]-octan-3-amine

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Basic Information

Synonyms: (2S,3S)-N-(5-tert-butyl-2-methoxybenzyl)-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine2-hydroxypropane-1,2,3-tricarboxylatehydrate(1:1:1) maropitant (2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)-methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]-octan-3-amine (2S,3S)-2-diphenylmethyl-3-(5-tert-butyl-2-methoxybenzyl)amino-1-azabicyclo[2.2.2]octane (2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]-octane-3-amine (2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)-methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine (2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine (2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo-[2.2.2]octan-3-amine (2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octane-3-amine

Molecular Formula: C32H40N2O

Molecular Weight: 468.68

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

(2S,3S)-N-(5-tert-butyl-2-methoxyphenyl)-methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]octan-3-amine is a complex chiral amine featuring a 1-azabicyclo[2.2.2]octane (quinuclidine) core structure. This specific stereoisomer is a key synthetic intermediate in the production of certain pharmaceutical compounds. Its primary and well-documented application is in the synthesis of Aprepitant (Emend®), a potent and selective neurokinin-1 (NK1) receptor antagonist. Aprepitant is used clinically for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV). The (2S,3S)-configured quinuclidine amine serves as a crucial chiral building block that directly contributes to the final drug's three-dimensional structure and pharmacological activity. The synthesis and supply of this high-purity intermediate are critical for the manufacturing process of Aprepitant and related NK1 antagonists, highlighting its importance in the pharmaceutical supply chain for antiemetic therapies.

Physical Properties