(S)-(-)-1-Boc-3-aminopyrrolidine, CAS No. 147081-44-5

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147081-44-5

Catalog No. EBD28307

CAS 147081-44-5

Name (S)-(-)-1-Boc-3-aminopyrrolidine

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Basic Information

Synonyms: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine (S)-(-)-1-Boc-3-aminopyrrolidine (S)-tert-Butyl3-aminopyrrolidine-1-carboxylate (S)-1-Boc-3-aminopyrrolidine (s)-(-)-N-Boc-3-aminopyrrolidine (S)-N-Boc-3-aminopyrrolidine (S)-1-N-Boc-3-Aminopyrrolidine tert-butyl(3S)-3-aminopyrrolidine-1-carboxylate 1-t-butoxycarbonyl-3-S-aminopyrrolidine (R)-5-(pyrrolidin-2-yl)-1H-tetrazole S-1-N-Boc-3-AminoPyrrolidine (3S)-(-)-3-Amino-1-Boc-Pyrrolidine

Molecular Formula: C9H18N2O2

Molecular Weight: 186.25

MDL Number: MFCD03419271

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine is a chiral, Boc-protected pyrrolidine derivative. It features a primary amino group at the 3-position of the pyrrolidine ring, which is a versatile functional handle for further chemical transformations, and a tert-butoxycarbonyl (Boc) group serving as a protective group for the secondary amine. This compound is a crucial chiral building block and intermediate in pharmaceutical synthesis. Its primary application is in the preparation of various active pharmaceutical ingredients (APIs), particularly those containing a chiral pyrrolidine scaffold. It has been cited in the synthesis of drug candidates targeting diverse therapeutic areas, including central nervous system disorders and infectious diseases. The molecule's structure makes it a valuable precursor for constructing complex, biologically active molecules. As a protected chiral amine, it is a common reagent in medicinal chemistry and asymmetric synthesis. The Boc group can be readily removed under acidic conditions to reveal the free secondary amine, allowing for sequential functionalization. It is typically handled and stored under inert conditions to ensure stability.

Physical Properties

Boiling Point: 216-217 °C(lit.)

Flash Point: 91 °C

Density: 1.067 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.4720(lit.)

Safety Information

Packing Level: III

Hazard Category: 6.1

Transport Codes: 2810

Analytical Data

Appearance: Colorless to light yellow liquid