Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

    OK
    Get Quote Login
    146307-51-9

    Catalog No. EBD992424

    CAS 146307-51-9

    Name trans-4-tert-Butoxycarbonylamino-cyclohexanecarboxylic acid methyl ester

    Get Quote
    Basic Information

    Synonyms: 4-tert-Butoxycarbonylamino-cyclohexanecarboxylicacidmethylester trans-4-tert-Butoxycarbonylamino-cyclohexanecarboxylicacidmethylester

    Molecular Formula: C13H23NO4

    Molecular Weight: 257.33

    MDL Number: MFCD17015041

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    Methyl trans-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate is a white to off-white crystalline powder. It is a bifunctional organic compound featuring a trans-cyclohexane ring substituted with a methyl ester group and a tert-butoxycarbonyl (Boc)-protected amino group. This specific stereochemistry (trans) is often crucial for its biological activity and synthetic utility. This compound is a versatile and important building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the preparation of various drug candidates, particularly those targeting the central nervous system (CNS). For instance, it is a critical precursor in the synthesis of certain serotonin and norepinephrine reuptake inhibitors (SNRIs) and other bioactive molecules where a rigid, trans-1,4-disubstituted cyclohexane scaffold is required. The Boc group serves as a standard protecting group for amines, allowing for selective deprotection and further functionalization during multi-step syntheses. Due to its well-defined structure and high purity, it is widely used in medicinal chemistry research for structure-activity relationship (SAR) studies and lead optimization. It is commercially available from major suppliers of fine chemicals and pharmaceutical intermediates, highlighting its established role in the industry.
    Physical Properties

    Storage: −20°C

    mg g kg ml l t