Selegiline hydrochloride, CAS No. 14611-52-0

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14611-52-0

Catalog No. EBD52087

CAS 14611-52-0

Name Selegiline hydrochloride

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Basic Information

Synonyms: (R)-(-)-deprenylhydrochloride SelegilineHydrochloride Selegilinehcl N-methyl-N-[(2R)-1-phenylpropan-2-yl]prop-2-yn-1-aminehydrochloride(1:1) N-methyl-N-(1-phenylpropan-2-yl)prop-2-yn-1-aminehydrochloride(1:1) N-ethynyl-N-methyl-1-phenylpropan-2-aminehydrochloride(1:1) R-(-)-Deprenylhydrochloride (R)-(-)-N,alpha-Dimethyl-N-(2-propynyl)phenethylaminehydrochloride

Molecular Formula: C13H18ClN

Molecular Weight: 223.74

Categories: Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs Medicinal Chemistry > Drug Impurities and Reference Standards > Impurity Standards

Product Description:

Selegiline hydrochloride is a selective and irreversible inhibitor of monoamine oxidase B (MAO-B). It is a white to off-white crystalline powder with the chemical name (R)-(-)-N,α-dimethyl-N-2-propynylphenethylamine hydrochloride. This compound is the hydrochloride salt form of selegiline, which enhances its stability and solubility for pharmaceutical formulation. As an active pharmaceutical ingredient (API), selegiline hydrochloride is primarily used in the treatment of Parkinson's disease. It functions by inhibiting the breakdown of dopamine in the brain, thereby increasing dopaminergic activity and alleviating motor symptoms. It is also used as an adjunct therapy in major depressive disorder. The compound is formulated into various dosage forms, including oral tablets and transdermal patches. Due to its established therapeutic use, selegiline hydrochloride is also relevant in pharmaceutical analysis. It serves as a reference standard or impurity standard in quality control and analytical method development for drug products containing selegiline, ensuring the identity, potency, and purity of the final medication.

Physical Properties

Color: white

Melting Point: 141-142°C

Boiling Point: 272.5 °C at 760mmHg

Flash Point: 108.4 °C

Solubility: H2O: >10 mg/mL

Analytical Data

Appearance: white Crystalline Solid