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    145987-00-4

    Catalog No. EBD3733877

    CAS 145987-00-4

    Name (R)-(+)-2-(PHENYLCARBAMOYLOXY)PROPIONIC ACID

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    Basic Information

    Synonyms: (2R)-2-[[(phenylamino)carbonyl]oxy]-Propanoicacid (R)-(+)-2-(PHENYLCARBAMOYLOXY)PROPIONICACID (R)-(+)-Browns (2R)-2-[(phenylcarbamoyl)oxy]propanoicacid

    Molecular Formula: C10H11NO4

    Molecular Weight: 209.2

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

    Product Description:
    (R)-(+)-2-[(Propylamino)carbonyloxy]propanoic acid is a chiral carboxylic acid derivative. It is structurally characterized by a propylcarbamoyloxy group attached to the alpha-carbon of a propionic acid backbone, with the (R)-configuration at the chiral center. This compound is a key chiral intermediate in the synthesis of important pharmaceutical agents. Its primary and most significant application is in the production of the anticonvulsant and neuropathic pain medication **Pregabalin** (marketed as Lyrica®). The (R)-enantiomer serves as a crucial building block to construct the pharmacologically active (S)-enantiomer of pregabalin through specific synthetic routes, ensuring high enantiomeric purity of the final Active Pharmaceutical Ingredient (API). As a specialized intermediate designed for a specific drug synthesis pathway, it is not considered a general-purpose synthetic building block. Its production and use are tightly linked to the manufacturing processes of pregabalin and related gabapentinoid drugs targeting the central nervous system.
    Physical Properties
    mg g kg ml l t