2,3-Difluorophenylacetic acid, CAS No. 145689-41-4

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145689-41-4

Catalog No. EBD992357

CAS 145689-41-4

Name 2,3-Difluorophenylacetic acid

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Basic Information

Synonyms: 23-DifluorophenylaceticAcid (2-Chloro-4-Fluorophenyl)AceticAcid (2,3-Difluorophenyl)Acetate Difluoro(Phenyl)AceticAcid 2,3-difluorophenylaceticacid RARECHEMALBO0630 2-(2,3-Difluorophenyl)AceticAcid 2,3-DifluorobenzeneaceticAcid

Molecular Formula: C8H6F2O2

Molecular Weight: 172.13

MDL Number: MFCD00040968

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

2,3-Difluorophenylacetic acid is an organic compound featuring a phenylacetic acid core structure with fluorine substituents at the 2- and 3- positions. It serves as a versatile fluorinated aromatic building block in organic synthesis. Its primary application is as a key pharmaceutical intermediate. The difluorophenyl moiety is a privileged structural motif in medicinal chemistry, often used to modulate the lipophilicity, metabolic stability, and binding affinity of drug candidates. This compound is specifically utilized in the synthesis of various active pharmaceutical ingredients (APIs) and drug candidates, particularly those targeting the central nervous system and other therapeutic areas. As a bifunctional molecule containing both a reactive carboxylic acid group and a fluorinated aromatic ring, it is a valuable synthon for constructing more complex molecules through amide bond formation, esterification, or further functionalization of the aromatic system.

Physical Properties

Melting Point: 116-119 °C(lit.)

Boiling Point: 258.1 °C at 760 mmHg

Flash Point: 109.9 °C

Density: 1.373 g/cm3