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    1454847-96-1

    Catalog No. EBD4029392

    CAS 1454847-96-1

    Name (S)-1-(5-fluoro-2-iodophenyl)ethan-1-ol

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    Basic Information

    Molecular Formula: C8H8FIO

    Molecular Weight: 266.05

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    (S)-1-(5-Fluoro-2-iodophenyl)ethan-1-ol is a chiral aromatic alcohol building block characterized by a stereogenic center and two halogen substituents (fluoro and iodo) on the phenyl ring. This specific substitution pattern and its defined (S)-configuration make it a valuable non-racemic intermediate in synthetic chemistry. Its primary application is in the pharmaceutical industry as a key chiral intermediate in the synthesis of active pharmaceutical ingredients (APIs). Research indicates its use in the development of novel therapeutic agents, particularly those targeting the central nervous system. The iodine atom serves as a versatile handle for further cross-coupling reactions (e.g., Suzuki, Sonogashira), allowing for rapid structural diversification, while the chiral alcohol functionality can be further modified or incorporated into the final drug scaffold. As a bifunctional molecule containing both a reactive aryl iodide and a chiral alcohol, it is also employed in academic and industrial research for constructing complex, halogenated, and optically active aromatic compounds. Standard safety precautions for handling halogenated and organoiodine compounds should be observed.
    Physical Properties
    mg g kg ml l t