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    1454843-78-7

    Catalog No. EBD3732368

    CAS 1454843-78-7

    Name (6R)-5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 5-(1,1-dimethylethyl) ester

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    Basic Information

    Synonyms: (R)-5-(TERT-BUTOXYCARBONYL)-5-AZASPIRO[2.4]HEPTANE-6-CARBOXYLIC ACID

    Molecular Formula: C12H18NO4-

    Molecular Weight: 240.28

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates

    Product Description:
    (R)-5-(tert-Butoxycarbonyl)-5-azaspiro[2.4]heptane-6-carboxylic acid is a chiral, spirocyclic amino acid derivative. Its structure features a unique 5-azaspiro[2.4]heptane scaffold, which is a constrained bicyclic system containing a nitrogen atom and a cyclopropane ring, with both a Boc-protected amine and a carboxylic acid functional group. This compound is primarily utilized as a key chiral building block or intermediate in pharmaceutical research and development. The spirocyclic and cyclopropane motifs are of high interest in medicinal chemistry for their ability to modulate the conformational, physicochemical, and metabolic properties of drug candidates. It is specifically cited in patent literature related to the synthesis of inhibitors targeting enzymes like Dihydroorotate Dehydrogenase (DHODH), which are being investigated for potential applications in autoimmune diseases and oncology. As a Boc-protected amino acid, it is designed for use in peptide coupling or further synthetic elaboration. The presence of the chiral center makes it valuable for constructing enantiomerically pure active pharmaceutical ingredients (APIs) or advanced intermediates.
    Physical Properties
    mg g kg ml l t