1-Benzyl-3-carbethoxy-4-piperidone hydrochloride, CAS No. 1454-53-1

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1454-53-1

Catalog No. EBD572326

CAS 1454-53-1

Name 1-Benzyl-3-carbethoxy-4-piperidone hydrochloride

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Basic Information

Synonyms: 1-benzyl-3-ethoxycarbonyl-4-piperidonehydrochloride 1-benzyl-3-methoxycarbonyl-4-piperidinonehcl 1-benzyl-4-piperidone-3-carboxylicacidethylesterhydrochloridehydrate methyl1-benzyl-4-oxo-piperidine-3-carboxylate labotest-bblt00159470 ethyl1-benzyl-4-oxo-3-piperidinecarboxylatehydrochloride ethyl1-benzyl-4-oxo-3-piperidinecarboxylatehydrochloridehydrate N-Benzyl-4-piperidone-3-carboxylicacidethylesterhydrochloride 1-Benzyl-3-(ethoxycarbonyl)-4-piperidonehydrochloride 1-Benzyl-3-carbethoxy-4-piperidonehydrochloride

Molecular Formula: C15H20ClNO3

Molecular Weight: 297.78

MDL Number: MFCD00012800

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

1-Benzyl-3-acetoxy-4-piperidone hydrochloride is a heterocyclic organic compound featuring a piperidone core substituted with a benzyl group at the N1 position and an acetoxy group at the C3 position, and is supplied as its hydrochloride salt. This white to off-white crystalline powder is a key chiral building block in organic synthesis. Its primary and most significant application is as a crucial intermediate in the pharmaceutical synthesis of fentanyl and its numerous analogues. The piperidone scaffold serves as the foundational structure for constructing the potent opioid's pharmacophore. The specific substitution pattern (benzyl, acetoxy) on this ring system directs subsequent chemical transformations towards the final active pharmaceutical ingredient (API). Due to its role in the synthesis of controlled substances, the handling, distribution, and use of this compound are subject to strict regulatory controls in many jurisdictions. It is primarily of interest in specialized pharmaceutical research and development settings focused on analgesic chemistry or forensic analysis.

Physical Properties

Melting Point: 175 °C (dec.)(lit.)

Boiling Point: 379.7 °C at 760 mmHg

Flash Point: 183.4 °C

Analytical Data

Appearance: pink to cream powder