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    145369-94-4

    Catalog No. EBD842653

    CAS 145369-94-4

    Name 6-bromo-4-hydroxyquinoline

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    Basic Information

    Synonyms: 6-bromo-4-hydroxyquinoline 6-bromo-4-quinolinol 6-bromo-quinolin-4-ol 6-Brom-chinolin-4-ol 6-bromoquinolin-4-ol 6-Bromo-4(1H)-quinolone 6-bromoquinolin-4(1H)-one 6-bromo-4-hyrdroxyquinoline

    Molecular Formula: C9H6BrNO

    Molecular Weight: 224.05

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    6-Bromo-4-hydroxyquinoline is a halogenated heterocyclic compound featuring a quinoline scaffold substituted with a bromine atom at the 6-position and a hydroxyl group at the 4-position. This structure makes it a versatile and valuable bifunctional building block in organic synthesis. Its primary application is as a key pharmaceutical intermediate. The bromine atom serves as an excellent site for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), while the hydroxyl group can be modified or act as a coordinating site. It is notably used in the synthesis of various biologically active molecules, including kinase inhibitors and other therapeutic agents targeting cancer and inflammatory diseases. As a synthetic building block, it is employed in the construction of more complex quinoline derivatives, ligands for metal complexes, and materials with potential optoelectronic properties. It is commercially available from suppliers specializing in fine chemicals and advanced intermediates for medicinal chemistry.
    Physical Properties

    Boiling Point: 321.713 °C at 760 mmHg

    Flash Point: 148.367 °C

    Density: 1.62 g/cm3

    mg g kg ml l t