1-(2-Hydroxy-5-nitrophenyl)ethanone, CAS No. 1450-76-6

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1450-76-6

Catalog No. EBD16707

CAS 1450-76-6

Name 1-(2-Hydroxy-5-nitrophenyl)ethanone

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Basic Information

Synonyms: 2'-hydroxy-5'-nitroacetophenone 2-hydroxy-5-nitroacetophenone 1-(5-nitro-2-hydroxyphenyl)ethanone nsc64461 1-(2-hydroxy-5-nitrophenyl)ethan-1-one 2'-hydroxy-5'-nitroacetophenone97% ethanone,1-(2-hydroxy-5-nitrophenyl)- 2-hydroxy-5-nitroacetetophenone 1-(2-Hydroxy-5-nitrophenyl)ethanone

Molecular Formula: C8H7NO4

Molecular Weight: 181.15

MDL Number: MFCD00463816

Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

Product Description:

1-(2-Hydroxy-5-nitrophenyl)ethanone is a substituted acetophenone derivative featuring a hydroxyl group at the ortho position and a nitro group at the meta position relative to the acetyl group. This molecular architecture makes it a valuable small molecule fragment in medicinal chemistry, particularly for constructing heterocyclic systems and bioactive compounds. The presence of both electron-donating (hydroxy) and electron-withdrawing (nitro) groups allows for versatile chemical modifications. As a synthetic building block, it is commonly employed in the synthesis of pharmaceutical intermediates, such as precursors for anti-inflammatory agents, antimicrobials, and kinase inhibitors. The hydroxyl group can undergo alkylation or acylation, while the nitro group can be reduced to an amine for further derivatization. Its utility extends to the preparation of Schiff bases and metal-chelating ligands. In the context of organic synthesis, it serves as a phenolic and ketone building block for constructing more complex molecular architectures.

Physical Properties

Melting Point: 100-104 °C(lit.)

Boiling Point: 285.5 °C at 760 mmHg

Flash Point: 126 °C

Density: 1.38 g/cm3