1-(5-Bromo-2-hydroxyphenyl)ethanone, CAS No. 1450-75-5

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1450-75-5

Catalog No. EBD21768

CAS 1450-75-5

Name 1-(5-Bromo-2-hydroxyphenyl)ethanone

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Basic Information

Synonyms: -bromo-o-hydroxyacetophenone 3-bromo-6-hydroxyphenylmethylketone 2-acetyl-4-bromophenol 5'-bromo-2'-hydroxyacetophenone 5-bromo-2-hydroxyacetophenone akosbbs-00006622 1-(5-bromo-2-hydroxyphenyl)-ethanon 2’-hydroxy-5’-bromoacetophenone 5’-bromo-2’-hydroxy-acetophenon 1-(5-bromo-2-hydroxyphenyl)ethanone 2'-hydroxy-5'-bromoacetophenone 5'-bromo-2'-hydroxy-acetophenon 2-Hydroxy-5-bromoacetophenone -hydroxy-5 acetophenone,5 -bromoacetophenone

Molecular Formula: C8H7BrO2

Molecular Weight: 215.04

MDL Number: MFCD00191850

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

Product Description:

5'-Bromo-2'-hydroxyacetophenone is an organic compound featuring both a bromine substituent and a phenolic hydroxyl group on an acetophenone core. It is a versatile bifunctional building block in synthetic organic chemistry. Its primary application is as a key intermediate in the synthesis of various heterocyclic compounds, particularly benzofurans and their derivatives. The presence of the ortho-bromo and ortho-hydroxy groups relative to the acetyl moiety allows for facile intramolecular cyclization reactions, such as the copper-catalyzed Ullmann-type coupling or palladium-catalyzed processes, to construct the benzofuran ring system. Benzofuran scaffolds are important structural motifs found in numerous pharmaceuticals, agrochemicals, and functional materials. This compound serves as a fundamental starting material in research laboratories for developing new chemical entities. Its reactivity profile makes it valuable for exploring novel synthetic routes and creating libraries of compounds for biological screening.

Physical Properties

Melting Point: 58-61 °C(lit.)

Boiling Point: 282.6 °C at 760 mmHg

Flash Point: 124.7 °C

Density: 1.586 g/cm3

Analytical Data

Appearance: white crystalline solid