2,8-Dichloroquinoline-3-carbaldehyde, CAS No. 144918-96-7

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144918-96-7

Catalog No. EBD251047

CAS 144918-96-7

Name 2,8-Dichloroquinoline-3-carbaldehyde

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Basic Information

Synonyms: 3-quinolinecarboxaldehyde,2,8-dichloro- 2,8-Dichloro-Quinoline-3-Carbaldehyde 2,8-Dichloroquinoline-3-Carboxaldehyde 2,8-Dichloroquinoline-3-carbaldehyde otava-bb7020617824 2,8-dichloroquinolin-3-carboxyaldehyde 2,8-dichloro-3-quinolinecarboxaldehyde

Molecular Formula: C10H5Cl2NO

Molecular Weight: 226.06

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

2,8-Dichloroquinoline-3-carbaldehyde is a halogenated quinoline derivative characterized by a formyl group at the 3-position and chlorine atoms at the 2- and 8-positions. This specific substitution pattern makes it a valuable and versatile synthetic building block, particularly in medicinal chemistry. Its primary application is as a key intermediate in the synthesis of various pharmacologically active compounds. The reactive aldehyde group serves as a handle for further chemical transformations, such as condensation reactions to form imines or hydrazones, or reduction to the corresponding alcohol. The dichloroquinoline core is a privileged scaffold found in molecules with diverse biological activities. While its most prominent use is in pharmaceutical research and development, its well-defined structure also qualifies it as a specialized organic synthesis block for constructing complex heterocyclic systems beyond drug discovery contexts.

Physical Properties

Boiling Point: 358.1 °C at 760 mmHg

Flash Point: 170.4 °C

Density: 1.483 g/cm3