2-Chloro-4-Aminopyridine, CAS No. 14432-12-3

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14432-12-3

Catalog No. EBD541074

CAS 14432-12-3

Name 2-Chloro-4-Aminopyridine

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Basic Information

Synonyms: 2-chloro-4-pyridinamine 2-chloropyridin-4-amine 4-amino-2-chloropyridinium 2-Chloro-4-Aminopyridine 4-amino-2-chloropyridine

Molecular Formula: C5H5ClN2

Molecular Weight: 128.56

MDL Number: MFCD00060089

Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Amines Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

2-Chloro-4-aminopyridine is a heterocyclic building block featuring a pyridine ring substituted with a chlorine atom at the 2-position and an amino group at the 4-position. This compound serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of kinase inhibitors and central nervous system (CNS) active agents. Its dual functional groups enable selective cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and further derivatization. Additionally, it is widely utilized as a versatile synthetic building block in medicinal chemistry for constructing complex heterocyclic scaffolds. The compound is typically handled as a solid and requires standard precautions for amines and halogenated aromatics.

Physical Properties

Melting Point: 90-94 °C(lit.)

Boiling Point: 153°C 5mm

Flash Point: 153°C/5mm

Density: 1.326 g/cm3

Analytical Data

Appearance: White powder