2,4-Difluorophenylboronic acid, CAS No. 144025-03-6

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144025-03-6

Catalog No. EBD435403

CAS 144025-03-6

Name 2,4-Difluorophenylboronic acid

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Basic Information

Synonyms: rarechemahpb0168 2,4-difluorobenzeneboronicacid 2,4-fluorobenzeneboronicacid akosbrn-0089 2,4-difluorophenylboricacid 2,4-difluorophenylboroicacid v2,4-difluorophenylboronicacid 2,4-Difluorophenyl-BoronicAcid 2,4-Difluorophenylboronicacid

Molecular Formula: C6H5BF2O2

Molecular Weight: 157.91

MDL Number: MFCD01318998

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

2,4-Difluorophenylboronic acid is an organoboron compound featuring a phenyl ring substituted with fluorine atoms at the 2- and 4- positions and a boronic acid functional group. It is a white to off-white crystalline powder and serves as a versatile building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions. Its primary application is as a key synthetic intermediate in the pharmaceutical industry. The 2,4-difluorophenyl moiety is a common structural motif found in various active pharmaceutical ingredients (APIs), including antifungal agents, kinase inhibitors, and other biologically active molecules. The boronic acid group enables efficient carbon-carbon bond formation with aryl or vinyl halides, facilitating the construction of complex drug candidates. This compound is commercially available from major chemical suppliers for research and development purposes. As with many boronic acids, it should be stored under inert conditions to prevent protodeboronation and handled with standard laboratory safety precautions.

Physical Properties

Melting Point: 247-250 °C(lit.)

Boiling Point: 251 ºC at 760 mmHg

Flash Point: 105.6 ºC

Density: 1.35 g/cm3

Storage: 0-6°C

Analytical Data

Appearance: off-white to light beige or yellow powder