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    143062-83-3

    Catalog No. EBD3321283

    CAS 143062-83-3

    Name (1R-CIS)2-FLUORO-CYCLOPROPANAMINE

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    Basic Information

    Synonyms: (1r,2s)-fluorocyclopropanamine (1r-cis)2-fluoro-cyclopropanaminetosylate (1R-CIS)2-FLUORO-CYCLOPROPANAMINE (1R,2S)-2-fluorocyclopropanamine Cyclopropanamine,2-fluoro-,(1R,2S)- Cyclopropanamine,2-fluoro-,(1R-cis)-

    Molecular Formula: C3H6FN

    Molecular Weight: 75.08

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (1R,2S)-2-Fluorocyclopropanamine is a chiral fluorinated cyclopropane derivative. It is a versatile building block characterized by its strained three-membered ring structure and the presence of both an amine and a fluorine substituent in a defined stereochemical configuration. This compound is primarily utilized as a key chiral intermediate in pharmaceutical research and development. Its unique structure allows for the introduction of the cyclopropane motif, which is a privileged scaffold in medicinal chemistry known to enhance metabolic stability, modulate lipophilicity, and influence the conformation of drug molecules. The fluorine atom can serve as a bioisostere for hydrogen or a hydroxyl group, potentially improving pharmacokinetic properties. It is particularly valuable in the synthesis of potential antiviral and antibacterial agents. As a specialized chiral amine, it is also employed in organic synthesis for constructing complex molecules. Its availability in enantiomerically pure form makes it a valuable reagent for asymmetric synthesis and the preparation of novel chemical entities for biological screening.
    Physical Properties

    Boiling Point: 58.143 °C at 760 mmHg

    Flash Point: -17.902 °C

    Density: 1.089 g/cm3

    mg g kg ml l t