Vinblastine sulfate, CAS No. 143-67-9

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143-67-9

Catalog No. EBD2197852

CAS 143-67-9

Name Vinblastine sulfate

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Basic Information

Synonyms: Vinblastinesulfate 29060le exal nsc49842 rozevinsulfate velban velbe vincaleukoblastine,sulfate(1:1)(salt) vinblastinesulfatesalt vinblastinesulphate VinblastinSulfate vincaleukoblastinesulfatesalt (2alpha,3alpha,4alpha,5beta,19beta)-vincaleukoblastine (2alpha,2'beta,3alpha,4alpha,5beta,19beta)-vincaleukoblastinesulfate(1:1) (2alpha,2'beta,3alpha,4alpha,5beta,19beta)-vincaleukoblastine (2alpha,2'beta,3alpha,4alpha,5beta,19beta)-vincaleukoblastinesulfate (2alpha,3alpha,4alpha,5beta,19beta)-vincaleukoblastinesulfate

Molecular Formula: C46H60N4O13S

Molecular Weight: 909.05

MDL Number: MFCD08706468

Categories: Medicinal Chemistry > APIs and Their Salts > Antineoplastic Agents Medicinal Chemistry > Biochemicals and Life Science Reagents > Phytochemicals and Natural Products

Product Description:

Vinblastine sulfate is a sulfate salt of vinblastine, a naturally occurring bisindole alkaloid derived from the Madagascar periwinkle plant, *Catharanthus roseus*. It is a complex molecule consisting of two multi-ringed indole units, catharanthine and vindoline, linked together. The compound is typically supplied as a white to slightly yellow, crystalline powder that is soluble in water and methanol. As a key antineoplastic agent, vinblastine sulfate is primarily used in the treatment of various cancers, most notably Hodgkin's and non-Hodgkin's lymphomas, as well as testicular cancer, breast cancer, and Kaposi's sarcoma. Its mechanism of action involves binding to tubulin, thereby inhibiting microtubule formation and arresting cell division during metaphase. This disrupts the mitotic spindle apparatus, leading to cell cycle arrest and apoptosis in rapidly dividing cells. Due to its potent cytotoxicity, vinblastine sulfate is classified as a hazardous substance and requires careful handling. It is administered intravenously under clinical supervision. As a plant-derived natural product, it is also a significant compound in pharmacological research and serves as a reference standard in analytical studies.

Physical Properties

Melting Point: 267 °C (dec.)(lit.)

Density: 1.37 g/cm3

Solubility: H2O: 10 mg/mL

Storage: 2-8°C

Analytical Data

Appearance: crystalline solid