(S)-Methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate, CAS No. 142569-69-5

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142569-69-5

Catalog No. EBD42654

CAS 142569-69-5

Name (S)-Methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate

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Basic Information

Synonyms: (S)-Methyl2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate methyl1-[E]-2-[3-(s)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropy]benzoate 2-[3-(S)-[3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl]-3-hydroxypropyl]BenzoicacidMETHYLESTERBenzoicacid,2-[3-(S)-[3-(E)-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-HydroxyAcidMethylEster[R-(E)-2-[3-[3-[2-(7-Chloro-2)[R-(E)-2-[3-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-oxopropyl]benzoicacidmethylester Methyl[E]-2-[3-(S)-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl]benzoate methyl2-[(3S)-3-{3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-hydroxypropyl]benzoate 3-(benzyloxy)-2-(4-chlorobenzyl)-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylicacid Benzoicacid2-(3-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)–methylester (S)-Methyl2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)ph

Molecular Formula: C28H24ClNO3

Molecular Weight: 457.95

MDL Number: MFCD09835558

Categories: Medicinal Chemistry > APIs and Their Salts > Respiratory Drugs Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates

Product Description:

This compound, with the CAS number 142569-69-5, is a key synthetic intermediate in the production of Montelukast. Its chemical name is Methyl 2-[3-(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl]benzoate. It is a chiral molecule featuring a quinoline ring, a styrene moiety, a hydroxypropyl chain, and a methyl benzoate group, which are all essential structural components for the final active pharmaceutical ingredient. The primary and definitive application of this chemical is in the synthesis of Montelukast sodium, a leukotriene receptor antagonist (LTRA) used as a maintenance treatment for asthma and to relieve symptoms of seasonal allergies. It serves as a crucial advanced intermediate in the multi-step manufacturing process of this blockbuster respiratory drug. Its synthesis and purification are critical steps to ensure the correct stereochemistry and efficacy of the final API. As a specialized intermediate with a complex, drug-like structure tailored for a specific therapeutic agent, it is not considered a general-purpose synthetic building block. Its handling requires standard laboratory precautions for organic compounds, and its production is tightly controlled within pharmaceutical supply chains dedicated to API manufacturing.

Physical Properties

Melting Point: 88-90 °C

Boiling Point: 643.972 °C at 760 mmHg

Flash Point: 343.262 °C

Density: 1.279 g/cm3

Analytical Data

Appearance: yellow solid