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    14161-84-3

    Catalog No. EBD2221155

    CAS 14161-84-3

    Name 2-(3-Chlorophenyl)propanoic acid

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    Basic Information

    Synonyms: 2-(3-Chlorophenyl)propanoicacid 2-(3-Chlorophenyl)PropionicAcid Benzeneaceticacid,3-chloro-2-methyl- 2-Methyl-2(3-chlorophenyl)aceticacid

    Molecular Formula: C9H9ClO2

    Molecular Weight: 184.62

    MDL Number: MFCD03412454

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Other Pharmaceutical Intermediates Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

    Product Description:
    2-(3-Chlorophenyl)propanoic acid is an organic compound featuring a phenyl ring substituted with a chlorine atom at the meta position and a propanoic acid side chain. It is a white to off-white crystalline powder. This compound is a versatile chiral building block, with the racemic form being commonly used in synthesis. Its primary application is as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs), most notably for the production of Ketoprofen, a widely used analgesic and anti-inflammatory agent. The structure allows for further chemical modifications to introduce the necessary ketone functionality and chiral center required for the active drug. As a substituted phenylpropionic acid derivative, it is a common motif in medicinal chemistry. Beyond its specific use in Ketoprofen synthesis, it represents a valuable synthetic intermediate for exploring other bioactive molecules with similar arylpropionic acid scaffolds.
    Physical Properties

    Boiling Point: 286.567 °C at 760 mmHg

    Flash Point: 127.111 °C

    Density: 1.264 g/cm3

    mg g kg ml l t