(S)-1-Boc-3-(hyroxymethyl)piperidine, CAS No. 140695-84-7

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140695-84-7

Catalog No. EBD46368

CAS 140695-84-7

Name (S)-1-Boc-3-(hyroxymethyl)piperidine

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Basic Information

Synonyms: (S)-N-Boc-piperdine-3-hydroxymethyl (s)-1-boc-3-(hyroxymethyl)piperidine 2-Methyl-2-propanyl(3R)-3-(hydroxymethyl)-1-piperidinecarboxylate tert-Butyl(3R)-3-(hydroxymethyl)piperidine-1-carboxylate tert-Butyl-(3R)-3-(hydroxymethyl)piperidin-1-carboxylat (S)-1-Boc-3-HydroxymethylPiperidine (S)-3-Hydroxymethyl-Piperidine-1-CarboxylicAcidTert-ButylEster (s)-1-n-boc-3-hydroxymethyl-piperidine (s)-1-boc-3-(hydroxymethyl)piperidine (s)-n-(tert-butoxycarbonyl)-3-hydroxymethylpiperidine (s)-tert-butyl3-(hydroxymethyl)tetrahydro-1(2h)-pyridinecarboxylate n-boc-(3s)-pip(3-ch2oh) 3-(s)-n-boc-piperidinemethanol (S)-tert-Butyl3-(hydroxymethyl)piperidine-1-carboxylate

Molecular Formula: C11H21NO3

Molecular Weight: 215.29

MDL Number: MFCD02683203

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-1-Boc-3-(hydroxymethyl)piperidine is a chiral piperidine derivative characterized by a Boc-protected amine group and a hydroxymethyl substituent at the 3-position. This compound serves as a versatile and valuable chiral building block in organic synthesis, particularly for the construction of complex molecules with a piperidine scaffold. Its primary application is in pharmaceutical research and development as a key intermediate. The chiral (S)-configuration and the presence of two orthogonal functional groups (protected amine and primary alcohol) make it a crucial precursor for synthesizing various bioactive compounds, including potential drug candidates. It has been specifically cited in patent literature for the synthesis of inhibitors targeting enzymes like dipeptidyl peptidase IV (DPP-4), which are relevant for treating type 2 diabetes. The compound is commercially available from suppliers specializing in fine chemicals and chiral intermediates for medicinal chemistry. Handling requires standard precautions for laboratory chemicals, and it should be stored under inert conditions to preserve its stability.

Physical Properties

Boiling Point: 308 °C at 760 mmHg

Flash Point: 140.1 °C

Density: 1.059 g/cm3