(S)-N-Boc-3-aminomethylpiperidine, CAS No. 140645-24-5

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140645-24-5

Catalog No. EBD54317

CAS 140645-24-5

Name (S)-N-Boc-3-aminomethylpiperidine

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Basic Information

Synonyms: (s)-3-aminomethyl-piperidine-1-carboxylicacidtert-butylester (s)-1-n-boc-3-(aminomethyl)piperidine (s)-1-n-boc-piperidine-3-methylamine (s)-1-boc-3-(aminomethyl)piperidine (s)-tert-butyl3-(aminomethyl)piperidine-1-carboxylate (s)-3-(aminomethyl)-1-n-boc-piperidine (S)-3-AMINOMETHYL-1-BOC-PIPERIDINE tert-butyl(3S)-3-(aminomethyl)piperidine-1-carboxylate (S)-3-(Aminomethyl)-1-Boc-piperidine S-1-Boc-3-(Aminomethyl)piperidine S-1-N-Boc-2-AminomethylPiperidine (S)-N-Boc-piperidine-3-methylamine (S)-N-Boc-3-aminomethylpiperidine (S)-1-BOC-3-(AMINOMETH

Molecular Formula: C11H22N2O2

Molecular Weight: 214.3

MDL Number: MFCD03839877

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(S)-N-Boc-3-aminomethylpiperidine is a chiral piperidine derivative featuring both a Boc-protected amine and a primary aminomethyl group. This bifunctional structure makes it a versatile and valuable building block in organic synthesis, particularly for the construction of complex molecules with a piperidine scaffold. Its primary application is as a key chiral intermediate in pharmaceutical research and development. The (S)-enantiomer is specifically utilized in the synthesis of various bioactive compounds and active pharmaceutical ingredients (APIs). For instance, it serves as a crucial precursor in the synthesis of certain kinase inhibitors and other therapeutic agents targeting the central nervous system and other disease areas. The Boc protecting group allows for selective manipulation of the secondary amine, while the primary amine provides a handle for further derivatization and linkage. As a high-purity chiral synthon, it is widely employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization. Its utility extends to the preparation of compound libraries and the development of novel drug candidates where the stereochemistry of the piperidine ring is critical for biological activity.

Physical Properties

Boiling Point: 299.4 °C at 760 mmHg

Flash Point: 134.9 °C

Density: 1.023 g/cm3