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    14036-96-5

    Catalog No. EBD209997

    CAS 14036-96-5

    Name 3-Bromo-6-methoxy-quinoline

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    Basic Information

    Synonyms: 3-bromo-6-methoxyquinoline 3-Bromo-6-methoxy-quinoline

    Molecular Formula: C10H8BrNO

    Molecular Weight: 238.08

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds

    Product Description:
    3-Bromo-6-methoxyquinoline is an organic compound featuring a quinoline core substituted with a bromine atom at the 3-position and a methoxy group at the 6-position. It is a solid with a molecular formula of C10H8BrNO and a molecular weight of 238.08 g/mol. This compound serves as a versatile and valuable building block in medicinal chemistry and organic synthesis. Its primary application is as a key synthetic intermediate in the development of pharmaceutical candidates. The bromine atom at the 3-position is a reactive site amenable to various cross-coupling reactions, such as Suzuki, Stille, or Buchwald-Hartwig couplings, enabling the introduction of diverse aryl, heteroaryl, or amine substituents. This makes it particularly useful for constructing complex heterocyclic scaffolds found in bioactive molecules. The 6-methoxy group can influence the electronic properties and solubility of the molecule. As a halogenated quinoline derivative, it is a fundamental organic synthesis block. It is commonly used in research settings to explore structure-activity relationships (SAR) and to synthesize libraries of compounds for biological screening. Standard safety precautions for handling halogenated aromatic compounds should be observed.
    Physical Properties

    Boiling Point: 318.3°C at 760 mmHg

    Flash Point: 146.3°C

    Density: 1.516g/cm3

    mg g kg ml l t