4-fluoro-2-methyl-phenyl boronic acid, CAS No. 139911-29-8

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139911-29-8

Catalog No. EBD50045

CAS 139911-29-8

Name 4-fluoro-2-methyl-phenyl boronic acid

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Basic Information

Synonyms: 4-Fluoro-o-tolylboronicacid 4-Fluoro-2-methylbenzenboronicacid 4-Fluoro-2-MethylphenylBoronicAcid 4-Fluoro-2-methylbenzeneboronicacid akosbrn-0102 4-fluoro-2-methylphenylboronicacid~4-fluoro-o-tolylboronicacid boronicacid,(4-fluoro-2-methylphenyl)-(9ci) 4-fluoro-2-methylphenylboronic 4-fluoro-2-methyl-phenylboronicacid 2-methyl-4-fluorophenylboronicacid (2-methyl-4-fluoro)phenylboronicacid (4-fluoro-2-methylphenyl)boronicacid 2-methyl-4-fluoro-phenylboronicacid

Molecular Formula: C7H8BFO2

Molecular Weight: 153.95

MDL Number: MFCD02093072

Categories: Synthetic Chemistry > Organic Building Blocks > Boronic Acids and Boronic Esters Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks

Product Description:

4-Fluoro-2-methylphenylboronic acid is an organoboron compound featuring a boronic acid functional group attached to a substituted benzene ring. It is a white to off-white crystalline powder with a molecular formula of C7H8BFO2 and a molecular weight of 153.95 g/mol. As a typical arylboronic acid, it is widely used as a key building block in Suzuki-Miyaura cross-coupling reactions, a fundamental method for constructing biaryl and heterobiaryl structures in organic synthesis. Its primary application is in the pharmaceutical industry as a versatile synthetic intermediate. The presence of both the boronic acid handle and the fluorine substituent makes it a valuable precursor for introducing the 4-fluoro-2-methylphenyl moiety into target molecules. This structural motif is found in various bioactive compounds and active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics. It serves as a crucial fragment in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization. The compound should be stored under inert conditions, typically at 2-8°C, to maintain stability. It is considered an irritant and requires standard laboratory safety precautions, including the use of personal protective equipment. Its role is firmly established in the toolbox of modern synthetic chemistry for constructing complex molecular architectures.

Physical Properties

Melting Point: 191-196 °C(lit.)

Boiling Point: 277.423 °C at 760 mmHg

Flash Point: 121.581 °C

Density: 1.203 g/cm3

Storage: Refrigerator (+4°C)

Analytical Data

Appearance: white to off-white powder