4-Thiouridine, CAS No. 13957-31-8

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13957-31-8

Catalog No. EBD226019

CAS 13957-31-8

Name 4-Thiouridine

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Basic Information

Synonyms: 4-thio-1-2-D-ribofuranosyl-(3H)-pyrimidine-2,4-dione 1-2-D-Arabinofuranosyl-4-thiouracil thiouridine,4- thiouridine 4-thiouridineapprox. 4-thio-d-uridine 4-sh-ur nsc518132 uridine,4-thio- Thiouridine(VAN) 1-beta-D-ribofuranosyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one 1-pentofuranosyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one 4-Thiouridine 4-thio-uridine 4-Thio-uridin 4-Thiouridin

Molecular Formula: C9H12N2O5S

Molecular Weight: 260.27

Categories: Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides Medicinal Chemistry > Drug Impurities and Reference Standards > Drug Metabolite References

Product Description:

4-Thiouridine is a modified nucleoside where the oxygen atom at the 4-position of the uracil base is replaced by a sulfur atom. This structural modification imparts unique photophysical and biochemical properties to the molecule. It is a solid compound with a molecular formula of C9H12N2O5S. Its primary application is in life science research as a versatile biochemical tool. 4-Thiouridine is readily incorporated into RNA by cellular RNA polymerases and is a key component of the thiol-specific labeling technique for RNA-seq (TUC-seq). This allows for the specific isolation and sequencing of newly synthesized RNA, enabling the study of transcriptional dynamics. It also serves as a fluorescent probe due to its distinct absorbance and emission properties upon excitation. Furthermore, it is used as a reference standard or metabolite in pharmaceutical analysis. The compound is sensitive to light and should be stored in the dark. It is used under controlled laboratory conditions for research purposes only.

Physical Properties

Density: 1.72 g/cm3

Storage: −20°C

Analytical Data

Appearance: Light yellow crystalline