Tiotropium bromide hydrate, CAS No. 139404-48-1

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

139404-48-1

Catalog No. EBD46856

CAS 139404-48-1

Name Tiotropium bromide hydrate

Get Quote

Basic Information

Synonyms: (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonanebromidehydrate(1:1:1) 7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonanebromidehydrate(1:1:1) TiotropiumBromideMonohydrate tiotropiumbromdie tiotropium (1a,2b,4b,5a,7b)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonanebromidehydrate Tiotropiumbromidehydrate Tiotropium Bromide hydrate

Molecular Formula: C19H24BrNO5S2

Molecular Weight: 490.43

MDL Number: MFCD08141831

Categories: Medicinal Chemistry > APIs and Their Salts > Respiratory Drugs Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

Tiotropium bromide monohydrate is a long-acting muscarinic antagonist (LAMA) used as an active pharmaceutical ingredient (API). It is chemically characterized as a quaternary ammonium compound derived from scopolamine, featuring a thiophene ring. Its primary and most significant application is in the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It works by blocking muscarinic receptors in the airways, leading to bronchodilation. It is the API in the globally marketed inhalation product "Spiriva." While its dominant use is respiratory, its mechanism of action as an anticholinergic agent also underpins its investigation and use in conditions related to the nervous system, such as overactive bladder, highlighting its pharmacological action on muscarinic receptors beyond the lungs.

Physical Properties