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    139399-67-0

    Catalog No. EBD254929

    CAS 139399-67-0

    Name 3-bromo-8-aminoquinoline

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    Basic Information

    Synonyms: 8-Quinolinamine,3-bromo- 3-Bromo-8-aminoquinoline 3-bromoquinolin-8-amine 8-amino-3-bromoquinoline 3-bromo-[8]quinolylamine 3-Brom-[8]chinolylamin 3-bromo-quinolin-8-ylamine

    Molecular Formula: C9H7BrN2

    Molecular Weight: 223.07

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    3-Bromo-8-aminoquinoline is an organic compound featuring a quinoline scaffold substituted with a bromine atom at the 3-position and an amino group at the 8-position. This structure makes it a versatile bifunctional building block, combining the reactivity of an aromatic amine and an aryl bromide. Its primary application is in medicinal chemistry as a key intermediate for the synthesis of various biologically active molecules. The 8-aminoquinoline moiety is a privileged structure in drug discovery, particularly known for its role in antimalarial agents (e.g., primaquine, tafenoquine) and other therapeutic areas. The bromine atom serves as a handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), enabling the rapid construction of diverse compound libraries for biological screening. As a heterocyclic amine with a halogen substituent, it is also widely used in organic synthesis as a specialized building block for constructing complex nitrogen-containing heterocycles and functional materials.
    Physical Properties
    mg g kg ml l t