(S)-3-Amino-4-phenylbutanoic acid hydrochloride, CAS No. 138165-77-2

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138165-77-2

Catalog No. EBD2200053

CAS 138165-77-2

Name (S)-3-Amino-4-phenylbutanoic acid hydrochloride

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Basic Information

Synonyms: (S)-3-Amino-4-phenylbutanoicacidhydrochloride beta-homophenylalaninehydrochloride l-beta-homophenylalanine l-beta-homophenylalaninehcl l-beta-homophenylalaninehydrochloride h-phe-(c*ch2)ohhcl h-beta-hophe-ohhcl h-beta-homophenylalaninehcl h-beta-homophe-ohhcl (3S)-3-amino-4-phenylbutanoicacidhydrochloride (3R)-3-amino-4-phenyl-butanoicacidhydrochloride H-β-HoPhe-OH.HCl H-β-HoPhe-OH

Molecular Formula: C10H14ClNO2

Molecular Weight: 215.68

MDL Number: MFCD01862875

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives

Product Description:

(S)-3-Amino-4-phenylbutanoic acid hydrochloride is a chiral, non-proteinogenic amino acid derivative. It features a phenylbutanoic acid backbone with an amino group at the β-position, and is provided as the hydrochloride salt to enhance its stability and solubility. The (S)-enantiomer is of particular interest due to its specific stereochemistry. This compound serves as a crucial chiral building block in pharmaceutical synthesis. Its primary application is as a key intermediate in the production of various active pharmaceutical ingredients (APIs), most notably for antihypertensive drugs. It is a fundamental precursor in the synthesis of renin inhibitors and other cardiovascular agents that target the renin-angiotensin system. The phenyl and carboxylic acid moieties provide essential pharmacophoric elements for drug-receptor interactions. As a chiral β-amino acid derivative, it is also utilized in peptide mimetics research and the development of novel bioactive compounds. Its handling requires standard precautions for amino acids and hydrochloride salts, including protection from moisture.

Physical Properties

Boiling Point: 329.5 °C at 760 mmHg

Flash Point: 153.1 °C