N-[(2'-cyanobiphenyl-4-yl)-methyl]-(L)-valine methyl ester, CAS No. 137863-89-9

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137863-89-9

Catalog No. EBD21200

CAS 137863-89-9

Name N-[(2'-cyanobiphenyl-4-yl)-methyl]-(L)-valine methyl ester

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Basic Information

Synonyms: 2-cyano[[[1,1'-biphenyl]-4-yl]methyl]-L-valinemethylester N-[(2'-cyanobiphenyl-4-yl)-methyl]-(L)-valinemethylester n-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-l-valinemethylester n-[(2'-cyano-(1,1'-biphenyl)-4-yl)methyl)]valinemethylester n-[(2'-cyanobiphenyl-4-yl)methyl]-l-valinemethylester n-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-l-valinemethylesterhcl n-[[(2∧-cyano(1.1∧-biphenyl)-4-ythyl)methylester]-l-l]evaline n-[[(2'-cyano(1.1'-biphenyl)-4 n-[[2'-cyano(1,1'-biphenyl)-4-ythyl]methylester]-l-1]evaline n-[[(2''-cyano(1,1''-biphenyl)-4-yl)methyl]methylester]-l-valine methylN-[(2'-cyanobiphenyl-4-yl)methyl]-L-valinate N-[(2'-Cyano-(1,1'-biphenyl)-4-yl)methyl]]valinemethylester methylN-[(2'-cyanobiphenyl-4-yl)methyl]-

Molecular Formula: C20H22N2O2

Molecular Weight: 322.4

MDL Number: MFCD08436153

Categories: Medicinal Chemistry > APIs and Their Salts > Cardiovascular Drugs

Product Description:

N-[(2'-Cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester, also known as Valsartan Hydrocarbonate or Valsartan Methyl Ester, is a key chiral intermediate in the synthesis of Valsartan. Valsartan is a widely prescribed angiotensin II receptor blocker (ARB) used for the treatment of hypertension (high blood pressure) and heart failure. This specific ester derivative is a crucial precursor in the manufacturing process, undergoing further chemical transformations such as hydrolysis and tetrazole ring formation to yield the final active pharmaceutical ingredient (API). The compound features a biphenyl core with a nitrile group and an L-valine methyl ester moiety, which are essential structural components for the biological activity of Valsartan. Its production and purity are critical for ensuring the quality and efficacy of the final drug product. As a dedicated pharmaceutical intermediate, it is not typically used as a general-purpose synthetic building block in other fields.

Physical Properties

Boiling Point: 477.9 °C at 760 mmHg

Flash Point: 242.8 °C

Density: 1.12