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    1378390-29-4

    Catalog No. EBD3329907

    CAS 1378390-29-4

    Name 3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one

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    Basic Information

    Synonyms: 3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one 3-(2-bromoacetyl)-10,11-dihydro-5H-Benzo[d]naphtho[2,3-b]pyran-8(9H)-one

    Molecular Formula: C19H15BrO3

    Molecular Weight: 371.22

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Targeted Protein Degradation Tools > Linkers

    Product Description:
    3-(2-bromoacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one is a heterocyclic organic compound featuring a dibenzo[c,g]chromenone core structure with a reactive 2-bromoacetyl substituent. This specific molecular architecture, particularly the bromoacetyl group, makes it a versatile electrophilic handle for chemical conjugation. Its primary application is in the field of targeted protein degradation, specifically as a key building block for the synthesis of Proteolysis-Targeting Chimeras (PROTACs). The compound serves as a precursor for "linkers" that connect the E3 ligase ligand to the target protein ligand. The bromoacetyl group can be readily substituted with nucleophiles (e.g., thiols from cysteine residues or other amine/heterocycle-containing moieties) to form stable covalent bonds, enabling the modular assembly of PROTAC molecules designed to degrade specific disease-causing proteins. This compound is a specialized research chemical used predominantly in medicinal chemistry and chemical biology for the development of novel degrader therapeutics. It is not a widely used general-purpose synthetic building block, but rather a tool for constructing sophisticated bifunctional molecules.
    Physical Properties

    Storage: −20°C

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