Di-tert-butyl N,N-diisopropylphosphoramidite, CAS No. 137348-86-8

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137348-86-8

Catalog No. EBD48635

CAS 137348-86-8

Name Di-tert-butyl N,N-diisopropylphosphoramidite

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Basic Information

Synonyms: Di-tert-butylN,N-diisopropylphosphoramidite Di-t-butylN,N-diisopropylphosphoramidite di-tert-butyldipropan-2-ylphosphoramidoite di-tert-butyldiisopropylphosphoramidite di-tert-butyl-n,n-diisopropylphosphoramidite di-tert-butyl-n,n-diisopropylphosphoroamidite n,n-bis(1-methylethyl)phosphoramidousacidbis(1,1-dimethylethyl)ester n,n-bisisopropylphosphoramidousacidbis(tert-butyl)ester n,n-diisopropylphosphoramidite di-tert-butyln,n-diisopropylphosphoramidite95% di-tert-butylN,N-diisopropylphosphor-amidite

Molecular Formula: C14H32NO2P

Molecular Weight: 277.38

MDL Number: MFCD00153506

Categories: Synthetic Chemistry > Organic Building Blocks > Phosphorus Compounds Synthetic Chemistry > Basic Synthetic Reagents > Protecting and Deprotecting Reagents

Product Description:

N,N-Diisopropylphosphoramidous acid di-tert-butyl ester is a key organophosphorus reagent, specifically a phosphoramidite. Its structure features a central phosphorus atom bonded to two tert-butoxy groups and a diisopropylamino group, making it a versatile precursor for the introduction of the di-tert-butyl phosphite protecting group. This compound is primarily employed in oligonucleotide synthesis and organic synthesis as a phosphitylating agent. It is used to prepare nucleoside phosphoramidites, which are the essential building blocks in solid-phase automated DNA/RNA synthesis. The di-tert-butyl phosphite group introduced by this reagent offers advantages in certain synthetic strategies due to its stability and specific deprotection conditions compared to more common protecting groups like cyanoethyl. As a specialized reagent, it is handled under inert atmosphere (argon or nitrogen) due to its sensitivity to moisture and air, which can lead to hydrolysis and degradation. Its use is predominantly confined to research and development laboratories focused on nucleic acid chemistry and the synthesis of phosphorus-containing compounds.

Physical Properties

Melting Point: 85-90 °C 0.2 mm Hg(lit.)

Boiling Point: 85-90 °C/0.2 mmHg(lit.)

Flash Point: 113 °C

Density: 0.879 g/mL at 25 °C(lit.)

Refractivity: n20/D 1.444(lit.)

Storage: 2-8°C

Analytical Data

Appearance: Clear Colourless Liquid