N-tert-Butoxycarbonyl-L-Lysine, CAS No. 13734-28-6

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13734-28-6

Catalog No. EBD30228

CAS 13734-28-6

Name N-tert-Butoxycarbonyl-L-Lysine

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Basic Information

Synonyms: boc-l-lysine boc-l-lysine-oh boc-l-lys-oh boc-lysine boc-lys-oh n-alpha-boc-l-lysine n-alpha-t-butoxycarbonyl-l-lysine n-alpha-t-boc-l-lysine n-alpha-(tert-butoxycarbonyl)-l-lysine N~2~-(tert-butoxycarbonyl)lysine N~6~-(tert-butoxycarbonyl)-L-lysine n-boc-l-lysine Nα-t-BOClysine N-tert-Butoxycarbonyl-L-Lysine

Molecular Formula: C11H22N2O4

Molecular Weight: 246.3

MDL Number: MFCD00038203

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

N-Boc-L-lysine is a protected derivative of the essential amino acid L-lysine, featuring a tert-butoxycarbonyl (Boc) group on the α-amino group. This white to off-white crystalline powder is a fundamental building block in peptide synthesis and medicinal chemistry. Its primary application is as a key intermediate in the solid-phase and solution-phase synthesis of peptides and peptidomimetics. The Boc protecting group is stable under basic conditions and can be selectively removed under mild acidic conditions, making it crucial for the sequential assembly of complex peptide chains. It is extensively used in the research and development of therapeutic peptides, protein engineering, and as a precursor for various bioactive compounds. Beyond peptide synthesis, N-Boc-L-lysine serves as a versatile synthon for introducing the lysine side chain into more complex molecular architectures. It is also used in the preparation of lysine-based dendrimers, polymers, and bioconjugates. As a protected amino acid, it is a staple reagent in both academic and industrial laboratories focused on life sciences and pharmaceutical research.

Physical Properties

Melting Point: ~205 °C (dec.)(lit.)

Boiling Point: 410.5 °C at 760 mmHg

Flash Point: 202 °C

Density: 1.113 g/cm3

Refractivity: 21.5 ° (C=2, MeOH)

Storage: 2-8°C

Analytical Data

Appearance: white to off-white powder