N-Boc-L-aspartic acid, CAS No. 13726-67-5

Welcome to iChemical.com!

In the below part, please select the country you want us to ship to: Please note that once you've selected a shipping country, all pricing information on our website will be automatically updated to include door-to-door shipping to the country you specified.

North America

South America

Africa

Europe

Asia

Oceania

13726-67-5

Catalog No. EBD52818

CAS 13726-67-5

Name N-Boc-L-aspartic acid

Get Quote

Basic Information

Synonyms: boc-l-asparticacid-oh boc-l-asp-oh boc-l-asparticacid boc-asparticacid n-t-butoxycarbonyl-l-aspaticacid n-tert-butyloxycarbonyl-l-asparticacid Boc-Asp-OH N-(tert-Butoxycarbonyl)-L-asparticacid (2S)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)succinicacid 13726-67-5 N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-asparticacid N-tert-Butoxycarbonyl-L-asparticacid tert-Butoxycarbonyl-L-asparticacid N-(tert-butoxycarbonyl)asparticacid (2S)-2-[(tert-butoxycarbonyl)amino]butanedioate N-(tert-butoxycarbonyl)-D-asparticacid Boc-DL-Asp-OH Boc-Asp-

Molecular Formula: C9H15NO6

Molecular Weight: 233.22

MDL Number: MFCD00037279

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Drug Synthesis Building Blocks Medicinal Chemistry > Biochemicals and Life Science Reagents > Amino Acids and Derivatives Synthetic Chemistry > Organic Building Blocks > Carboxylic Acids and Esters

Product Description:

N-Boc-L-aspartic acid is a protected derivative of the natural amino acid L-aspartic acid, featuring a tert-butoxycarbonyl (Boc) group on the α-amino nitrogen. This white to off-white crystalline powder is a crucial chiral building block in organic synthesis, particularly in peptide chemistry. The Boc group serves as a standard, acid-labile protecting group for amines, allowing for selective deprotection under mild acidic conditions without affecting other functional groups. Its primary application is in the solid-phase and solution-phase synthesis of peptides and peptidomimetics. As a protected aspartic acid derivative, it is essential for introducing the aspartyl residue into peptide chains, which is important for creating biologically active sequences. It is widely used in the research and development of pharmaceutical intermediates, especially for drugs targeting the central nervous system, hormones, and enzyme inhibitors. It also serves as a precursor for synthesizing more complex amino acid derivatives and conjugates. Beyond peptide synthesis, Boc-L-aspartic acid is a valuable intermediate in medicinal chemistry for constructing drug candidates and in biochemical research for preparing enzyme substrates or inhibitors. It must be stored in a cool, dry place, and standard safety precautions for handling fine chemicals should be observed.

Physical Properties

Melting Point: 116-118 °C(lit.)

Boiling Point: 377.4 °C at 760 mmHg

Flash Point: 182.1 °C

Density: 1.302 g/cm3

Storage: Store at RT.

Analytical Data

Appearance: white crystalline powder