1-Piperidinecarboxylic acid, 4-formyl-, 1,1-dimethylethyl ester, CAS No. 137076-22-3

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137076-22-3

Catalog No. EBD265394

CAS 137076-22-3

Name 1-Piperidinecarboxylic acid, 4-formyl-, 1,1-dimethylethyl ester

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Basic Information

Synonyms: 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde 4-Formyl-Piperidine-1-CarboxylicAcidTert-ButylEster 1-Boc-4-Piperidinecarboxaldehyde 1-Boc-4-Formylpiperidine 1-Tert-Butoxycarbonylpiperidine-4-CarboxylAldehyde 1-N-Boc-4-Formylpiperidine N-Boc-4-Piperidinylcarboxaldehyde N-Boc-4-Formylpiperidine 1-N-Boc-4-piperidinecarboxaldehyde 1-Piperidinecarboxylicacid,4-formyl-,1,1-dimethylethylester tert-butyl4-formylpiperidine-1-carboxylate N-BOC-4-piperidinecarboxaldehyde N-BOC-4-piperidinecarboxyaldehyde

Molecular Formula: C11H19NO3

Molecular Weight: 213.27

MDL Number: MFCD02179019

Categories: Synthetic Chemistry > Organic Building Blocks > Amines Synthetic Chemistry > Organic Building Blocks > Aldehydes and Ketones

Product Description:

1-Piperidinecarboxylic acid, 4-formyl-, 1,1-dimethylethyl ester, commonly known as 1-Boc-piperidine-4-carboxaldehyde, is a key heterocyclic building block featuring a piperidine ring protected by a tert-butoxycarbonyl (Boc) group at the 1-position and a reactive aldehyde functional group at the 4-position. This structure combines a versatile nitrogen heterocycle with a protected amine, making it highly valuable in medicinal chemistry. Its primary application is as a synthetic intermediate in the pharmaceutical industry, particularly for constructing diverse drug candidates targeting the central nervous system, oncology, and infectious diseases. The aldehyde moiety allows for further functionalization through reductive amination, Grignard reactions, or condensation reactions, while the Boc group provides orthogonal protection during multi-step synthesis. It is widely used in the preparation of kinase inhibitors, GPCR modulators, and other bioactive molecules. Additionally, this compound serves as a fundamental organic synthesis building block for constructing more complex piperidine derivatives. Its stability and commercial availability make it a standard reagent in both research and process chemistry laboratories for developing novel chemical entities.

Physical Properties

Melting Point: 34-40 °C

Boiling Point: 295.4 °C at 760 mmHg

Flash Point: >110 °C

Density: 1.114 g/cm3

Solubility: water: at 25 deg C (mg/L): 708.2

Storage: 2-8°C

Safety Information

Packing Level: III

Hazard Category: 9

Transport Codes: 3077