(R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one, CAS No. 137036-55-6

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137036-55-6

Catalog No. EBD254299

CAS 137036-55-6

Name (R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one

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Basic Information

Synonyms: (+)-±-aminobenzlactam (r)-3-amino-2,3,4,5-tetrahydro-1h-1-benzazepin-2-one (3r)-amino-1,3,4,5-tetrahydro-2h-1-benzazepin-2-one (r)-3-amino-2-oxo-2,3,4,5-tetrahydro-1h-benzo[b]azepine 2h-1-benzazepin-2-one,3-amino-1,3,4,5-tetrahydro-,(3r)- r-3-amino-1,3,4,5-tetrahydro-benzo[b]azepin-2-one (3R)-3-amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one (R)-3-amino-2,3,4,5-tetrahydro-1-benzazepin-2-one 3(R)-amino-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one (3R)-3-amino-1,3,4,5-tetrahydro-1-benzazepin-2-one 3(R)-amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one

Molecular Formula: C10H12N2O

Molecular Weight: 176.22

MDL Number: MFCD01076210

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > APIs and Their Salts > Nervous System Drugs

Product Description:

(R)-3-amino-2,3,4,5-tetrahydro-1H-[1]-benzazepin-2-one is a chiral benzazepinone derivative, specifically a (R)-enantiomer. It serves as a crucial chiral intermediate in the synthesis of various pharmaceutical compounds. Its primary and most significant application is in the synthesis of (R)-(-)-O-desmethylvenlafaxine, which is the active metabolite of the antidepressant drug Venlafaxine. This metabolite is being investigated for its own therapeutic potential. The compound's structure, featuring a chiral amine and a fused benzazepinone ring system, makes it a key building block for constructing molecules that interact with neurological targets. As a high-value pharmaceutical intermediate, it is used in research and development for central nervous system (CNS) active drugs. Its synthesis and availability are of particular interest in medicinal chemistry for creating enantiomerically pure compounds aimed at treating depression and related disorders.

Physical Properties

Boiling Point: 377.5°Cat760mmHg

Flash Point: 182.1°C

Density: 1.143g/cm3