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    1363382-99-3

    Catalog No. EBD3728280

    CAS 1363382-99-3

    Name N-[(3R,4S)-4-fluoro-3-piperidinyl]-Carbamic acid 1,1-dimethylethyl ester

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    Basic Information

    Synonyms: tert-butyl N-[cis-4-fluoropiperidin-3-yl]carbamate

    Molecular Formula: C10H19FN2O2

    Molecular Weight: 218.27

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates

    Product Description:
    N-[(3R,4S)-4-fluoro-3-piperidinyl]-Carbamic acid 1,1-dimethylethyl ester is a chiral fluorinated piperidine derivative. It features a Boc-protected amino group and a fluorine atom on the piperidine ring, making it a valuable building block in medicinal chemistry. This compound is primarily used as a key intermediate in the synthesis of pharmaceutical active ingredients. Its structural motif, combining a fluorinated heterocycle with a protected amine, is particularly relevant for the development of kinase inhibitors and other small molecule therapeutics targeting various diseases. The fluorine atom is often introduced to modulate the metabolic stability, lipophilicity, and binding affinity of the final drug candidate. As a Boc-protected amine, it serves as a versatile synthon that can be readily deprotected and further functionalized. Its defined stereochemistry (3S,4R) is crucial for achieving the desired biological activity in enantiomerically pure drug substances.
    Physical Properties
    mg g kg ml l t