3-Amino-5-bromopyridine, CAS No. 13535-01-8

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13535-01-8

Catalog No. EBD12463

CAS 13535-01-8

Name 3-Amino-5-bromopyridine

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Basic Information

Synonyms: chembrdg-bb4006048 5-bromo-pyridin-3-ylamine 5-bromo-3-aminopyridine 5-bromopyridin-3-amine 3-amino-5-bronopyridine 3-amino-5-boromopyridine 3-Pyridinamine,5-bromo- 5-Brom-3-pyridinamin 5-Brompyridin-3-amin 5-chloropyridin-3-amine 5-Bromo-3-pyridinamine 3-Amino-5-bromopyridine

Molecular Formula: C5H5BrN2

Molecular Weight: 173.01

MDL Number: MFCD01646060

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

3-Amino-5-bromopyridine is an organic compound featuring a pyridine ring substituted with an amino group at the 3-position and a bromine atom at the 5-position. This structure makes it a versatile bifunctional building block, containing both a nucleophilic amine and an electrophilic aryl halide suitable for cross-coupling reactions. Its primary and most significant application is as a key pharmaceutical intermediate. It serves as a crucial precursor in the synthesis of various biologically active molecules, particularly kinase inhibitors and other heterocyclic drug candidates. The presence of both halogen and amino groups allows for sequential functionalization, enabling the construction of complex molecular architectures central to modern medicinal chemistry. Beyond its role in drug discovery, 3-amino-5-bromopyridine is a valuable reagent in general organic synthesis and materials science research. It is commonly used to introduce the aminopyridine moiety into larger structures. The compound requires careful handling as it may cause skin and eye irritation.

Physical Properties

Melting Point: 65-69 °C

Boiling Point: 287.6 ºC at 760mmHg

Flash Point: 127.7 ºC

Density: 1.71 g/cm3

Analytical Data

Appearance: Light yellow crystal