Boc-N-Me-Tyr(Me)-OH·DCHA is a protected amino acid derivative, specifically the dicyclohexylamine (DCHA) salt of N-(tert-butoxycarbonyl)-N-methyl-O-methyl-L-tyrosine. It features a tert-butoxycarbonyl (Boc) protecting group on the amine, a methyl group on the amide nitrogen (N-methylation), and a methyl ether on the tyrosine phenolic hydroxyl group (O-methylation). This multi-protected form renders the molecule stable and suitable for specific peptide synthesis strategies. This compound is a crucial building block (synthetic intermediate) in solid-phase peptide synthesis (SPPS) and solution-phase peptide chemistry. The N-methylation and O-methylation modifications are introduced to impart specific conformational and pharmacological properties to the final peptide sequence, such as enhanced metabolic stability, altered receptor selectivity, and improved membrane permeability. It is extensively used in the research and development of therapeutic peptides, peptidomimetics, and bioactive probes. The DCHA salt form improves the compound's crystallinity and handling properties. As a specialty, non-natural amino acid derivative, it is a key reagent for medicinal chemists and peptide scientists aiming to explore structure-activity relationships and develop novel peptide-based pharmaceuticals targeting various diseases.