(R)-N-Boc-2-Hydroxymethylmorpholine, CAS No. 135065-71-3

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135065-71-3

Catalog No. EBD2219047

CAS 135065-71-3

Name (R)-N-Boc-2-Hydroxymethylmorpholine

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Basic Information

Synonyms: (r)-2-hydroxymethylmorpholine-4-carboxylicacidtert-butylester 2-(hydroxymethyl)morpholine-4-carboxylicacid(r)-tert-butylester (r)-4-boc-2-hydroxymethyl-morpholine tert-butyl(2r)-2-(hydroxymethyl)morpholine-4-carboxylate (r)-4-t-butoxycarbonyl-2-(hydroxymethyl)morpholine 4-morpholinecarboxylicacid,2-(hydroxymethyl)-,1,1-dimethylethylester,(2r)- (r)-2-hydroxymethyl-4-boc-morpholine (R)-N-Boc-2-Hydroxymethylmorpholine

Molecular Formula: C10H19NO4

Molecular Weight: 217.26

MDL Number: MFCD09260605

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

(R)-N-Boc-2-Hydroxymethylmorpholine is a chiral morpholine derivative characterized by a protected amine (Boc group) and a hydroxymethyl substituent. This compound serves as a versatile and valuable chiral building block in organic synthesis, particularly in the pharmaceutical industry. Its primary application is as a key chiral intermediate in the synthesis of various active pharmaceutical ingredients (APIs). The morpholine ring is a privileged scaffold found in numerous drugs, and the chiral center at the 2-position is crucial for biological activity. This compound has been specifically cited in the synthesis of complex molecules, including potential kinase inhibitors and other therapeutic agents where stereochemical control is essential. The Boc protecting group allows for selective deprotection and further functionalization. As a bifunctional molecule containing both a protected amine and a hydroxyl group, it enables diverse chemical transformations. It is commonly used to introduce the chiral morpholine moiety into target structures, making it a sought-after intermediate for medicinal chemistry and process research.

Physical Properties

Boiling Point: 320.7 °C at 760 mmHg

Flash Point: 147.8 °C

Density: 1.118 g/cm3

Analytical Data

Appearance: White crystal