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    134855-88-2

    Catalog No. EBD3130561

    CAS 134855-88-2

    Name (R)-4-(1-aminoethyl)phenol

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    Basic Information

    Synonyms: Phenol,4-[(1R)-1-aminoethyl]-

    Molecular Formula: C8H11NO

    Molecular Weight: 137.18

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (R)-4-(1-aminoethyl)phenol is a chiral aromatic amine derivative, specifically the (R)-enantiomer of 4-(1-aminoethyl)phenol. It features a phenol group and a primary amine group attached to a chiral center on the ethyl side chain. This compound is a high-purity building block used in asymmetric synthesis. Its primary and most significant application is as a key chiral intermediate in the pharmaceutical industry. It serves as a crucial precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and cardiovascular diseases. For instance, it is a fundamental component in the synthesis of (R)-Norphenylephrine, a selective α1-adrenergic receptor agonist, and is involved in routes to produce other bioactive molecules like (R)-Sotalol, a beta-blocker. Due to its well-defined chiral center and the presence of both phenolic and amino functional groups, it is also valued in organic chemistry as a versatile chiral synthon for constructing more complex molecular architectures, especially in medicinal chemistry research.
    Physical Properties
    mg g kg ml l t