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    134575-14-7

    Catalog No. EBD2321419

    CAS 134575-14-7

    Name (1R,5S,6r)-benzyl 6-(hydroxymethyl)-3-aza-bicyclo[3.1.0]hexane-3-carboxylate

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    Basic Information

    Synonyms: 3-Azabicyclo[3.1.0]hexane-3-carboxylicacid,6-(hydroxymethyl)-,phenylmethylester,(1α,5α,6α)-

    Molecular Formula: C14H17NO3

    Molecular Weight: 247.29

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates

    Product Description:
    (1alpha,5alpha,6alpha)-3-Cbz-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane is a chiral, nitrogen-containing bicyclic compound featuring a fused cyclopropane ring. Its structure incorporates a carboxybenzyl (Cbz) protecting group on the nitrogen atom and a hydroxymethyl substituent, making it a versatile and advanced synthetic building block. This compound is primarily utilized as a key chiral intermediate in pharmaceutical research and development. Its rigid, three-dimensional bicyclic scaffold is of significant interest for constructing complex molecules with potential biological activity. The presence of both a protected amine and a primary alcohol provides handles for further chemical modifications, enabling its incorporation into target structures. The specific stereochemistry (1alpha,5alpha,6alpha) is crucial for its intended applications, as it can impart desired pharmacological properties to the final drug candidate. It is a specialized intermediate rather than a commodity chemical, typically used in the synthesis of novel therapeutic agents, particularly those targeting the central nervous system or as enzyme inhibitors.
    Physical Properties
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