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    1345413-20-8

    Catalog No. EBD3325233

    CAS 1345413-20-8

    Name (1S,2R)-2-(3,4-difluorophenyl)Cyclopropan-1-amine

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    Basic Information

    Synonyms: (1S,2R)-2-(3,4-difluorophenyl)Cyclopropan-1-amine

    Molecular Formula: C9H9F2N

    Molecular Weight: 169.17

    Categories: Synthetic Chemistry > Organic Building Blocks > Halogenated Compounds Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (1S,2R)-2-(3,4-difluorophenyl)cyclopropan-1-amine is a chiral cyclopropylamine derivative featuring a 3,4-difluorophenyl substituent. Its structure combines a strained cyclopropane ring with a primary amine and a difluorinated aromatic moiety, offering both conformational rigidity and electronic modulation. This compound is primarily utilized as a key small-molecule fragment and chiral building block in medicinal chemistry, particularly for the synthesis of kinase inhibitors and central nervous system (CNS) active agents. The (1S,2R) stereochemistry is critical for target binding affinity and selectivity in drug discovery programs. It is commonly employed in the development of novel therapeutic candidates targeting oncology and neurological disorders, where the difluorophenyl group enhances metabolic stability and lipophilicity.
    Physical Properties

    Boiling Point: 212.5±40.0 °C at 760 mmHg

    Flash Point: 99.0±14.4 °C

    Density: 1.3±0.1 g/cm3

    mg g kg ml l t