H-Ala-OBut·HCl, CAS No. 13404-22-3

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13404-22-3

Catalog No. EBD2198196

CAS 13404-22-3

Name H-Ala-OBut·HCl

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Basic Information

Synonyms: alanine-otbuhcl l-alaninet-butylesterhydrochloride l-alaninet-butylesterhydrochloridesalt l-alaninetert-butylesterhydrochloride l-ala-t-butylesterhcl h-ala-obuthcl h-ala-otbuhcl h-ala-otbuhydrochloride tert-butyll-alaninatehydrochloride H-Ala-OtBu.HCl (2S)-1-tert-butoxy-1-oxopropan-2-aminiumchloride L-Alaninetert.butylesterhydrochloride H-Ala-OtBu·HCl H-Ala-OBut·HCl

Molecular Formula: C7H16ClNO2

Molecular Weight: 181.66

MDL Number: MFCD00035524

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

Product Description:

L-Alanine tert-butyl ester hydrochloride is a white to off-white crystalline powder. It is a protected derivative of the natural amino acid L-alanine, where the carboxylic acid group is masked as a tert-butyl ester and the amino group is present as a hydrochloride salt. This protection enhances its solubility in organic solvents and makes it a versatile chiral building block. This compound is primarily used as a key chiral intermediate in the pharmaceutical industry for the synthesis of various peptide-based drugs and active pharmaceutical ingredients (APIs). Its chiral purity is crucial for producing enantiomerically pure final products. It serves as a fundamental unit in solid-phase peptide synthesis (SPPS) and solution-phase peptide coupling reactions. Beyond its primary pharmaceutical applications, L-alanine tert-butyl ester hydrochloride is also a valuable reagent in general organic synthesis and medicinal chemistry research for introducing the alanine moiety into more complex molecular architectures. It should be stored in a cool, dry place, and handled with appropriate personal protective equipment.

Physical Properties

Melting Point: 168-175 °C (dec.)

Boiling Point: 163.1 °C at 760 mmHg

Flash Point: 37 °C

Refractivity: 2.0 ° (C=2, EtOH)

Storage: 2-8°C