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    1335523-82-4

    Catalog No. EBD4028058

    CAS 1335523-82-4

    Name (S)-3-(4-Bromophenyl)piperidine

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    Basic Information

    Molecular Weight: 0.0

    Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Heterocyclic Intermediates Synthetic Chemistry > Organic Building Blocks > Amines

    Product Description:
    (S)-3-(4-Bromophenyl)piperidine is a chiral piperidine derivative featuring a 4-bromophenyl substituent at the 3-position. It is a high-purity building block commonly supplied as a hydrochloride salt or free base, with typical purities exceeding 97% (HPLC). Its molecular structure combines a saturated nitrogen heterocycle with an aromatic bromo group, making it a versatile intermediate for introducing a specific chiral pharmacophore. This compound is primarily utilized in medicinal chemistry research and pharmaceutical development as a key chiral intermediate. The bromophenyl group serves as a handle for further cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), while the piperidine scaffold is a privileged structure found in numerous bioactive molecules. It is specifically cited in patent literature and research targeting central nervous system (CNS) agents, receptor modulators, and other therapeutic candidates requiring a defined stereochemistry. As a specialized chiral amine, it is commercially available from suppliers of advanced pharmaceutical intermediates and fine chemicals. Handling requires standard precautions for laboratory chemicals, and it should be stored in a cool, dry place under inert atmosphere to maintain stability. Its primary value lies in enabling efficient synthesis of enantiomerically pure compounds for drug discovery programs.
    Physical Properties
    mg g kg ml l t