3'-Azido-3'-deoxythyMidine β-D-glucuronide, SodiuM Salt, CAS No. 133525-01-6

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133525-01-6

Catalog No. EBD2218898

CAS 133525-01-6

Name 3'-Azido-3'-deoxythyMidine β-D-glucuronide, SodiuM Salt

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Basic Information

Synonyms: aztglucuronide 3'-azido-3'-deoxythymidinebeta-d-glucuronide,sodiumsalt 3'-azido-3'-deoxythymidineb-d-*glucuronidesodiu 3'-azido-3'-deoxythymidineb-d-glucuronide,sodiumsalt 3'-azido-3'-deoxythymidineo-d-glucuronidesodiumsalt zidovudineglucuronide 3'-azido-3'-deoxy-d-thymidine-b-d-glucuronidesodiumsalt zidovudinebeta-d-glucuronide Thymidine,3'-azido-3'-deoxy-5'-O-β-D-glucopyranuronosyl-,monosodiumsalt 3'-Azido-3'-deoxythyMidineβ-D-glucuronide,SodiuMSalt 3-Azido-3-deoxythymidine-D-glucuronide,SodiumSalt 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium

Molecular Formula: C17H23N5NaO9

Molecular Weight: 464.38

Categories: Medicinal Chemistry > Drug Impurities and Reference Standards > Drug Metabolite References Medicinal Chemistry > Biochemicals and Life Science Reagents > Saccharides, Nucleosides, and Nucleotides

Product Description:

3'-Azido-3'-deoxythymidine β-D-glucuronide, sodium salt is a chemically defined metabolite of the antiviral drug zidovudine (AZT). It is formed in vivo through the conjugation of AZT with glucuronic acid, a major Phase II metabolic pathway. This compound is a nucleoside analogue glucuronide conjugate, specifically the sodium salt form, which enhances its solubility in aqueous solutions. This sodium salt is primarily used as a certified reference standard in bioanalytical research and pharmaceutical development. It serves as a critical calibrant for the accurate quantification of AZT and its metabolites in biological matrices (e.g., plasma, urine) using techniques like liquid chromatography-mass spectrometry (LC-MS/MS). Its availability as a high-purity standard is essential for pharmacokinetic studies, drug metabolism and disposition (DMPK) investigations, and regulatory bioequivalence assessments of zidovudine formulations. As a well-characterized metabolite standard, it aids in understanding the clearance mechanisms and exposure profiles of AZT. Handling requires standard laboratory precautions for biochemical reagents.

Physical Properties