(S)-(+)-1-(2-Chlorophenyl)-1,2-ethanediol, CAS No. 133082-13-0

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133082-13-0

Catalog No. EBD31330

CAS 133082-13-0

Name (S)-(+)-1-(2-Chlorophenyl)-1,2-ethanediol

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Basic Information

Synonyms: (s)-2-(2-chlorophenyl)ethane-1,2-diol (1s)-1-(2-chlorophenyl)ethane-1,2-diol (s)-(+)-1-(2-chlorophenyl)-12-& (1s)-1-(2-chlorophenyl)ethane-1,2-diol95% (1s)-1-(2-chlorophenyl)ethane-1,2-diol,95% (1s)-1-(2-chlorophenyl)-1,2-ethanediol (S)-(+)-1-(2-chlorophenyl)-1,2-ethanediol (s)-1-(2-chlorophenyl)-1,2-ethanediol 1,2-ethanediol,1-(2-chlorophenyl)-,(s)-

Molecular Formula: C8H9ClO2

Molecular Weight: 172.61

MDL Number: MFCD01863241

Categories: Medicinal Chemistry > Pharmaceutical Intermediates > Chiral Intermediates Synthetic Chemistry > Organic Building Blocks > Phenols and Ethers

Product Description:

(S)-(+)-1-(2-Chlorophenyl)-1,2-ethanediol is a chiral diol compound featuring a 2-chlorophenyl substituent. It is a white to off-white crystalline solid with a specific rotation of approximately +40° (c=1, CHCl3). The compound contains both a primary and a secondary hydroxyl group, making it a versatile chiral building block. This compound is primarily used as a key chiral intermediate in the synthesis of pharmaceutical active ingredients. Its most notable application is in the production of Clopidogrel, a widely used antiplatelet drug (e.g., Plavix). The (S)-configuration of the molecule is crucial for the biological activity of the final drug product. The presence of the chlorophenyl group and the two hydroxyls allows for selective functionalization and further chemical transformations. As a chiral synthon, it is valuable in asymmetric synthesis and medicinal chemistry research. It is typically handled under inert atmosphere and stored in a cool, dry place.

Physical Properties

Melting Point: 68-75 °C(lit.)

Boiling Point: 293 °C(lit.)

Flash Point: 108 °C

Density: 1.328g/cm3